Publications and Links on Complex Systems /
Systems Biology in Acute Illness
| Neugebauer E, Rixen D, Raum M,
Schafer U. Thirty years of anti-mediator treatment in sepsis and septic
shock--what have we learned?(PubMed Link) |
| Kirschner, D. Dynamics of
co-infection with M. Tuberculosis and HIV-1. (PubMed Link) |
| Seely AJ, Christou NV. Multiple organ
dysfunction syndrome: exploring the paradigm of complex nonlinear systems. (PubMed Link) |
| Buchman TG, Cobb JP, Lapedes AS, Kepler
TB. Complex systems analysis: a tool for shock research. (PubMed Link) |
| Neugebauer EA, Willy C, Sauerland S.
Complexity and non-linearity in shock research: reductionism or synthesis? (PubMed Link) |
| Wigginton J.E., Kirschner, D. A model to
predict cell-mediated immune regulatory mechanisms during human infection with
Mycobacterium tuberculosis. (PubMed Link) |
| Ellenby, M. S., McNames, J., Lai, S.,
McDonald, B. A., Krieger, D., Sclabassi, R. J., Goldstein B. Uncoupling and
recoupling of autonomic regulation of the heart beat in pediatric septic shock.
(PubMed Link) |
| Hlavacek, W. S., Redondo, A., Metzger, H.,
Wofsy, C., Goldstein, B. Kinetic proofreading models for cell signaling predict
ways to escape kinetic proofreading. (PubMed Link) |
| Tjardes T, Neugebauer E. Sepsis research
in the next millennium: concentrate on the software rather than the hardware.
(PubMed Link) |
| An, G. Agent-based computer simulation and
SIRS: building a bridge between basic science and clinical trials. (PubMed Link) |
| Chinnaiyan AM, Huber-Lang M, Kumar-Sinha
C, Barrette TR, Shankar-Sinha S, Sarma VJ, Padgaonkar, VA, Ward PA. Molecular
signatures of sepsis: multiorgan gene expression profiles of systemic
inflammation. (PubMed Link) |
| Cobb JP, Laramie JM, Stormo GD, Morrissey
JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, Hotchkiss RS. Sepsis gene
expression profiling: murine splenic compared with hepatic responses determined
by using complementary DNA microarrays. (PubMed Link) |
| Ellenby MS, McNames J, Lai S, McDonald BA,
Krieger D, Sclabassi RJ, Goldstein B. Uncoupling and recoupling of autonomic
regulation of the heart beat in pediatric septic shock. (PubMed Link) |
| Cameron RJ, Sleigh JW. Chaotic sepsis and
the magic bullet. (PubMed Link) |
| Janes KA, Albeck JG, Peng LX, Sorger PK,
Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase
assay for monitoring information flow in signaling networks: application to
sepsis-apoptosis. (PubMed Link) |
| Goldstein, B., McNames, J., McDonald, B.
A., Ellenby, M., Lai, S., Sun, Z., Krieger, D., Sclabassi, R. J. Physiologic
data acquisition system and database for the study of disease dynamics in the
intensive care unit. (PubMed Link) |
| Neugebauer E, Tjardes T and the
Multidisciplinary Working Group on Complexity, New Approaches to Shock and
Trauma Research: Learning from Multidisciplinary Exchange (PubMed Link) |
| Goldstein B., Faeder J.R., Hlavacek W.S.
Mathematical and computational models of immune-receptor signalling. (PubMed Link) |
| Kumar R, Clermont, G, Vodovotz, Y, Chow
CC. The dynamics of acute inflammation. J.Theoretical Biol. 2004. (PubMed Link) |
| An, G. In-silico experiments of existing
and hypothetical cytokine-directed clinical trials using agent based modeling.
Crit Care Med. 2004. (PubMed Link) |
| Vodovotz Y., Clermont G., Chow C., An G.
Mathematical models of the acute inflammatory response. Curr.Opin.Crit Care
2004.(PubMed Link) |
| Clermont, G., Chow, C. C., Constantine, G.
M., Vodovotz, Y., Bartels, J. Mathematical and Statistical Modeling of Acute
Inflammation. Proc.Internatl.Fed.Classific.Soc. 2004.(In Press) |
| Vodovotz, Y., Chow, C. C., Bartels, J.,
Lagoa, C., Kumar, R., Day, J., Rubin, J., Constantine, G., Billiar, T. R.,
Fink, M. P., Clermont, G. In silico models of acute inflammation in
animals. Shock 2004.(In Press) |
| Vodovotz, Y., Kim, P., Bagci, E. Z.,
Ermentrout, G. B., Chow, C. C., Bahar, I., Billiar T. R.. Inflammatory
modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in
silico studies. Curr.Mol.Med. 2004.(PubMed Link) |
| Clermont, G., Bartels, J., Kumar, R.;
Constantine, G., Vodovotz, Y., Chow, C. In silico design of clinical trials: a
method coming of age. Crit Care Med. 2004.(PubMed Link) |
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